Eficacia del tratamiento farmacológico para el cierre del conducto arterioso persistente en recién nacidos prematuros.

Abstract

Patent ductus arteriosus (PDA) is a common heart disease in premature neonates, whose pharmacological treatment has been shown to be an effective alternative to avoid surgery. This systematic review analyzed the efficacy and safety of indomethacin, ibuprofen and paracetamol in PDA closure. NSAIDs were found to be effective, but may cause adverse effects, while paracetamol is presented as an option with less renal and gastrointestinal impact. It is concluded that the selection of the treatment should consider the clinical profile of the neonate, prioritizing its safety and efficacy. It is recommended to continue with comparative studies to optimize therapeutic management and reduce complications associated with PDA.